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1.
Chinese Circulation Journal ; (12): 969-972, 2018.
Article in Chinese | WPRIM | ID: wpr-703911

ABSTRACT

Objectives: This study aims to determine the risk factors of new-onset atrial fibrillation (AF) in patients who underwent isolated coronary artery bypass grafting (CABG) to provide evidences for the prevention and treatment of new-onset AF after CABG. Methods: Between January 2015 and May 2016, a total of 602 patients who underwent CABG in our department were retrospectively analyzed. The patients were divided into the AF group and the non-AF group, according to the occurrence of post-operative AF. A comparative analysis was performed on the general characteristics and perioperative data of the patients. Univariate and multivariate logistic analysis was used to identify the predictors of new-onset AF after CABG. Results: 128 patients developed AF post CABG. Left ventricular ejection fraction was significantly lower in AF group than that in non-AF group (P<0.05), while the left ventricular end diastolic diameter (LVEDD) and left atrium diameter (LAD) were significantly larger in AF group than in non-AF group (all P<0.05). Moreover, mechanical ventilation time and ICU stay were significantly longer in AF group than in non-AF group (both P<0.05). Logistic univariate analyses showed that a history of hyperlipidemia (OR=1.738, P=0.019), higher left atrium diameter (OR=1.097, P=0.001), higher NYHA classes (OR=1.689, P=0.004), and use of nitrates (OR=2.196,P=0.030) were associated with new-onset AF after CABG. After adjusting for age and gender, multivariate analyses showed that higher NYHA classes (OR=1.597, P=0.007) and LAD enlargement (OR=1.113, P=0.0001) remained as independent risk factors for new-onset AF after CABG. Conclusions: Higher NYHA classes and LAD enlargement are independent risk factors for new-onset AF after CABG.

2.
Chinese Medical Journal ; (24): 1032-1036, 2015.
Article in English | WPRIM | ID: wpr-350356

ABSTRACT

<p><b>BACKGROUND</b>No data on the incidence of pleural effusion (PE) in Chinese patients with pulmonary embolism are available to date. The aim of the current study was to investigate the frequency of PE in a Chinese population of patients with pulmonary embolism.</p><p><b>METHODS</b>This was a retrospective observational single-center study. All data of computed tomography pulmonary angiography (CTPA) performed over 6-year period on adult patients with clinically suspected pulmonary embolism were analyzed.</p><p><b>RESULTS</b>From January 2008 until December 2013, PE was identified in 423 of 3141 patients (13.5%) with clinically suspected pulmonary embolism who underwent CTPA. The incidence of PE in patients with pulmonary embolism (19.9%) was significantly higher than in those without embolism (9.4%) (P < 0.001). Majority of PEs in pulmonary embolism patients were small to moderate and were unilateral. The locations of emboli and the numbers of arteries involved, CT pulmonary obstruction index, and parenchymal abnormalities at CT were not associated with the development of PE.</p><p><b>CONCLUSIONS</b>PEs are present in about one fifth of a Chinese population of patients with pulmonary embolism, which are usually small, unilateral, and unsuitable for diagnostic thoracentesis.</p>


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Incidence , Pleural Effusion , Diagnostic Imaging , Epidemiology , Pulmonary Embolism , Diagnostic Imaging , Epidemiology , Radiography , Retrospective Studies
3.
Acta Anatomica Sinica ; (6): 310-315, 2014.
Article in Chinese | WPRIM | ID: wpr-452051

ABSTRACT

Objective To investigate the neuroprotective effect and mechanism of astragalus injection in cerebral ischemia reperfusion injury in rats .Methods A total of 70 healthy adult male Wistar rats were subjected to establish middle cerebral artery occlusion reperfusion models by inserting a monofilament thread from the external -internal carotid artery and treated by injecting 1g/L intraperitoneally astragalus injection (3ml/kg).The neurobehavioral function of rats was evaluated by Longa ’ s test and the cerebral infarction volume was calculated by tetrazolium chloride staining .The shape and ultrastructure of neurons in parietal cortex were observed by HE stain TEM .The early apoptotic ratio of neurons was detected by flow cytometry .The expressions of c-Jun N-terminal kinase 3 ( JNK3) mRNA and protein were determined by RT-PCR and Western blotting , respectively.Results After treatment with astragalus injection , the expressions of JNK3 mRNA and protein reduced significantly , the number of neuronal apoptosis in parietal cortexminus , the cerebral infarction volume shrink, the neuronal shape and ultrastructure and animal neurobehavioral function were improved significantly than those in model group rats .Conclusion The results suggest that astragalus injection may inhibit neuronal apoptosis , reduce the infarction volume and improve the animal neurobehavioral function by down -regulated the expression of JNK 3 gene following cerebral ischemia in rats .

4.
Chinese Journal of Gastrointestinal Surgery ; (12): 851-854, 2011.
Article in Chinese | WPRIM | ID: wpr-321223

ABSTRACT

<p><b>OBJECTIVE</b>To explore the application value of multi-slice spiral CT angiography (MSCTA) for the preoperative evaluation of laparoscopic right hemicolectomy.</p><p><b>METHODS</b>Abdominal CT slice images of 160 patients(group A) were collected for 3-dimensional reconstruction using volume rendering technique. Interpretation and anatomical classification of the major branches and course of the superior mesenteric artery(SMA) in the reconstructed images of the arterial phase were carried out. Forty-five patients(group B) undergoing laparoscopic right hemicolectomy were evaluated with MSCT combining images obtained from the arterial phase and portal venous phase. The relationship between ileocolic artery and ileocolic vein was analyzed. The preoperative imaging findings were compared to that revealed during the procedure.</p><p><b>RESULTS</b>In group A, 70(43.8%) out of 160 patents showed anatomical variations of the superior mesenteric artery, of whom 51(31.9%) had two right colic arteries, and 14(8.8%) had two middle colic arteries. Preoperative MSCTA showed that in group B ileocolic artery was running ventrally to ileocolic vein in 13(28.9%) out of 45 patients, while running dorsally in 32(71.1%). Compared to the skeletonized vessels during the procedure, the consistency rate was 100%.</p><p><b>CONCLUSION</b>Anatomical variations of superior mesenteric artery are common, therefore, multi-slice spiral CT scan is vital for preoperation evaluation.</p>


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Young Adult , Angiography , Methods , Colectomy , Methods , Laparoscopy , Mesenteric Artery, Superior , Diagnostic Imaging , Prospective Studies , Tomography, Spiral Computed , Methods
5.
Chinese Journal of Cardiology ; (12): 506-509, 2008.
Article in Chinese | WPRIM | ID: wpr-243744

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the genetic pathogenesis of dilated cardiomyopathy (DCM) by examining the heterogeneity of Coxsackievirus binding domain (exon 4) of Adenovirus receptor (CAR) in DCM patients and healthy adults, and to detect possible mutation site in exon 4.</p><p><b>METHODS</b>Using polymerase chain reaction (PCR), we amplified exon 4 of CAR DNA extracted from blood samples obtained from 50 DCM patients and 40 healthy adults. The PCR products were screened with single-strand conformation polymorphism (SSCP) and then sequenced alternatively based on the SSCP results.</p><p><b>RESULTS</b>The segment of CAR exon 4 was successfully amplified and there was no single strand conformational disparity in all samples examined by SSCP. Sequence analysis demonstrated that all amplified sequences of CAR exon 4 from samples of the two groups were identical and there was no genetic heterogeneity of CAR exon 4 between the two groups.</p><p><b>CONCLUSION</b>The genetic heterogeneity of CAR exon 4 might not be responsible for the pathogenesis of DCM.</p>


Subject(s)
Adult , Female , Humans , Male , Base Sequence , Cardiomyopathy, Dilated , Genetics , Virology , Coxsackievirus Infections , Genetics , Enterovirus , Genetics , Exons , Genes, Viral , Molecular Sequence Data , Polymorphism, Single-Stranded Conformational , Receptors, Virus , Genetics , Sequence Analysis, DNA
6.
International Eye Science ; (12): 613-617, 2007.
Article in Chinese | WPRIM | ID: wpr-641690

ABSTRACT

AIM: To evaluate the clinical outcomes of management in younger patients with primary chronic angle-closure glaucoma (PCACG).METHODS: Thirty-eight patients (50 eyes) aged 40 or younger with confirmed diagnosis of PCACG in advanced or late stage who received surgical treatment in Zhongshan Ophthalmic Center from January 2000 to December 2005were retrospectively investigated. All patients underwent trabeculectomy. The mean follow-up was 23.6±7.5 months.Full ophthalmic examinations were performed. The clinical outcomes including clinical presentations, surgical results and complications were evaluated.RESULTS: The mean age of patients was 33.5±6.1 years old. There was a female preponderance (60.5%). The mean axial length was 22.4±3.5mm with 18.0% short axis of eyeball and 14% nanophthalmos. There was 60.0% fiat anterior chamber depth (<1.9mm). Ultrasonic Biomicroscopy identified that plateau iris was the most common underlying etiology (80.6%). There was a statistically significant difference in intraocular pressure (IOP) reduction postoperativelyvs preoperatively (P<0.001). Four eyes failed to control IOP and received second filtration surgery. The main postoperative complications included shallow anterior chamber (20.0%) and malignant glaucoma (12.0%).CONCLUSION: The younger PCACG patients in advanced or late stage can be effectively managed by trabeculectomy.They have more frequency of postoperative sustained shallow anterior chamber and malignant glaucoma. Careful ophthalmic examinations, delicate surgical procedures and well-managed technique of complications were suggested on younger PCACG patients.

7.
Chinese Journal of Information on Traditional Chinese Medicine ; (12)2006.
Article in Chinese | WPRIM | ID: wpr-581070

ABSTRACT

Objective To investigate the year rhythm of laryngeal cough.Methods To record the attack months,the syndromes of TCM and degrees of symptoms in detail and analyze the data by percentage and Ridit analysis.Results The periods of laryngeal cough are in spring(March to May) and in autumn(September to November).The syndromes of TCM such as wind violating lung are commonly coughed in spring and primarily mild degree.The syndromes of TCM such as fire hyperactivity are commonly coughed in autumn and primarily moderate degree.Conclusions There is significant year rhythm in laryngeal cough.To master the rhythm can help the diagnosis and treatment.

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